Matrix metalloproteinase levels in the differentiation of parapneumonic pleural effusions.

نویسندگان

  • Smaragda Oikonomidi
  • Konstantinos Kostikas
  • Ioannis Kalomenidis
  • Irene Tsilioni
  • Christos Daenas
  • Konstantinos I Gourgoulianis
  • Theodoros S Kiropoulos
چکیده

BACKGROUND Matrix metalloproteinases (MMPs) have been implicated in the escalation of fibrosis and remodeling which are central to the subsequent progression of a parapneumonic pleural effusion to empyema. OBJECTIVES The aim of this study was the assessment of MMP-2, MMP-8 and MMP-9 in parapneumonic pleural effusions in order to examine their value in the differentiation between uncomplicated and complicated parapneumonic effusions. METHODS The study included 208 consecutive patients with pleural effusions [60 parapneumonic (27 uncomplicated parapneumonic, 17 complicated parapneumonic, 16 empyemas), 24 tuberculous, 89 malignant and 35 transudates]. Concentrations of pleural fluid and serum MMP-2, MMP-8 and MMP-9 were determined by immunoassay. RESULTS Pleural fluid MMP-8 and MMP-9 levels were higher in complicated parapneumonic effusions or empyema than in uncomplicated effusions, while their serum levels were higher in complicated parapneumonic effusions. MMP-2 levels were higher in uncomplicated than in complicated parapneumonic effusions or empyema. Pleural fluid MMP-2/MMP-9 ratio was the best marker to differentiate complicated from uncomplicated parapneumonic effusions, with a sensitivity of 94.1% and a specificity of 77.8% at a cut-off point of 1.32 (AUC = 0.887). CONCLUSIONS Pleural fluid MMP-2, MMP-8 and MMP-9 may provide useful information for differentiating between uncomplicated and complicated parapneumonic effusions.

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عنوان ژورنال:
  • Respiration; international review of thoracic diseases

دوره 80 4  شماره 

صفحات  -

تاریخ انتشار 2010